The New Orleans Saints are a heavy favorite winning 84% of simulations over the Buffalo Bills. Drew Brees is averaging 284 passing yards and 2.5 TDs per simulation and Darren Sproles is projected for 54 rushing yards and a 34% chance of having at least 1 rushing TD. In the 15% of simulations where Buffalo Bills wins, Thaddeus Lewis averages 0.86 TD passes vs 0.32 interceptions, while in losses he has a ratio of 0.5 TDs to 0.61 interceptions. C.J. Spiller averages 118 rushing yards and 0.91 rushing TDs when Buffalo Bills wins and 69 yards and 0.31 TDs in losses. New Orleans Saints has a 48% chance of forcing more turnovers than they commit. Positive turnover margin helps them win 96% of the time.